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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are often described as focusing on practical aspects of designing a study that include recruitment and consent, adherence and the use of routinely available equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and included participants from various geographical areas. This type of heterogeneity which is vital for pragmatic trials to be reliable and to reduce bias in the results is also essential. Too much heterogeneity, however, can cause problems with the design of the trial.
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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically commissioned by policy makers and practitioners to guide their decision-making. They are also a good method to determine the causality between the intervention and its effects. However, they should not, be used to replace explanatory studies.
프라그마틱 슬롯 추천 of pragmatism is controversial and there are doubts regarding whether pragmatic trials could be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool was designed to define the characteristics of a pragmatic study which includes the recruitment process, the design and delivery of the intervention, as well as the follow-up.
There is a growing increase in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority of these studies were conducted in primary-care settings.